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14,15 However, subsequent functional studies indicated that CTR1 mediates basolateral copper uptake (blood to intestinal cells) rather than apical transport (lumen to intestinal cells), 16 a result supported by more recent studies of CTR1 intestinal knockout mice which also revealed that the original apical CTR1 signal may have come from non-absorptive epithelial cells

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[4] [6] Understanding how tirzepatide works is essential when considering discontinuation, as its effects on glucose metabolism, gastric motility, and appetite regulation do not persist indefinitely after stopping treatment